ABSTRACT Starch is a major source of energy in the human diet and is consumed in diverse forms.Resistant starch (RS) escapes small intestinal digestion and is fermented in the colon by the resident microbiota, with beneficial impacts on colonic function and host health, but the impacts of the micro- and nanoscale structure of different physical for
Integrative omics analyses broaden treatment targets in human cancer
Abstract Background Although large-scale, next-generation Smoothing Shampoo sequencing (NGS) studies of cancers hold promise for enabling precision oncology, challenges remain in integrating NGS with clinically validated biomarkers.Methods To overcome such challenges, we utilized the Database of Evidence for Precision Oncology (DEPO) to link drugga
Poly (A) binding protein 2 is critical for stem cell differentiation during regeneration in the planarian Schmidtea mediterranea
Post-transcriptional regulation has emerged as a key mechanism for regulating stem cell renewal and differentiation, which is essential for understanding tissue regeneration and homeostasis.Poly(A)-binding proteins are a family of RNA-binding proteins that play a vital role in post-transcriptional regulation by controlling mRNA stability and protei